What is Cagri? Cagrilintide is a synthetic long-acting amylin analogue of the natural hormone amylin.

How does Cagri work? It works by: Delaying gastric emptying, prolonging the feeling of fullness after meals. Promoting satiety in the brain's hypothalamus. Reducing food cravings and portion sizes. Suppressing glucagon secretion, which helps manage blood glucose levels. Potentially improving metabolic flexibility. 

What are the potential applications? Cagrilintide is primarily being investigated as a treatment for obesity and related metabolic disorders, such as type 2 diabetes. It has shown promising results in animal trials and initial clinical studies, leading to reduced food intake and weight loss. It's often studied in combination with GLP-1 receptor agonists like semaglutide (found in drugs like Ozempic, Wegovy, and Rybelsus). The combination (marketed as CagriSema) may provide enhanced weight loss and glucose control compared to either drug alone. There's also speculation about its potential benefits in other conditions like liver damage and heart disease, but more research is needed.